New derivatives of saikosaponin c.
نویسندگان
چکیده
منابع مشابه
synthesis of new heterocyclic system n7-ethyl-5-methyl[1,2,4]triazolo[4,3:1,2]pyrimido[4,5d][1,3]thiazol-7-amine & synthesis of novel 7-methyl-3,5-di(alkhylsulfanyl) [1,2,4]triazolo[4,3-c]pyrimidine derivatives
در این تحقیق، ابتدا از واکنش 5-برمو-2-کلرو-6- متیل-4-پیریمیدین آمین (1) با هیدرازین هیدرات در حلال اتانول، 5-برومو-2-هیدرازینو -6-متیل -4-پیریمیدین آمین (2) به دست آمد. سپس از واکنش این ترکیب با تری اتیل اورتو استر های مختلف در حلال استیک اسید محصولات تری آزولوپیریمیدین (a,b3) حاصل گردید. همچنین از واکنش مشتق هیدرازین دار (2) با سدیم نیتریت در حلال استیک اسید و آب حد واسطی ایجاد شده است که از ر...
15 صفحه اولDevelopment of an assay system for saikosaponin a using anti-saikosaponin a monoclonal antibodies.
For immunization, saikosaponin a (SSa) was conjugated with bovine serum albumin (BSA). The hapten number in an antigen conjugate was determined to be eleven by matrix-assisted laser adsorption/ionization time-of-flight mass spectrometry (MALDI-TOF Mass). Hybridomas secreting monoclonal antibodies (MAb) against SSa were produced by fusing splenocytes immunized with SSa-BSA conjugate and a hypoxa...
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متن کاملFormulations, hemolytic and pharmacokinetic studies on saikosaponin a and saikosaponin d compound liposomes.
The aim of this study was to develop and optimise a saikosaponin a and saikosaponin d compound liposome (SSa-SSd-Lip) formulation with reduced hemolysis and enhanced bioavailability. A screening experiment was done with Plackett-Burman design, and response surface methodology of five factors (EPC/SSa-SSd ratio, EPC/Chol ratio, water temperature, pH of PBS, and ultrasound time) was employed to o...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1989
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.37.1293